Hybrid Fabrication

Femtosecond direct laser writing processes enable hybrid microfabrication of additive and subtractive technologies to create integrated systems. By selective laser etching (SLE), glass microstructures can be made and polymeric structures can be integrated into the glass microstructures using multiphoton polymerization (MPP).

The hybrid-fabrication approach enables rapid production of channels out of fused silica via laser ablation, while multiphoton polymerization is used to integrate fine-mesh 3D filters of arbitrary geometry inside the channel.

By using a hybrid microfabrication approach, complex lab-on-chip devices can be produced. The Channel system is made by using the Selective Laser Etching technique (SLE). Polymeric filters are integrated inside the prepared microfluidic system by using multi-photon polymerization (MPP).

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Lab-on-Chip Device
Examples Applications Industries Products Publications

Manufacturing examples

Lab-on-Chip Device

The hybrid-fabrication approach enables rapid production of channels out of fused silica via laser ablation, while multiphoton polymerization is used to integrate fine-mesh 3D filters of arbitrary geometry inside the channel.

Liver-on-Chip

The channels in the glass along with polymeric micropillars form a microfluidic device where different types of inserted cells can form a complex cellular architecture and manipulate cell‑to-cell interactions.

Micromechanical Sensor

By selective laser etching (SLE), glass microstructures can be made and polymeric structures can be integrated into the glass microstructures using multiphoton polymerization (MPP).

Application fields

Sensors

Multi-photon polymerization (MPP) enables the production of precise and strong microlenses and microneedles for visualization, filtering, and drug delivery. MPP can also be combined with other fabrication techniques such as selective laser etching to create hybrid microfabricated systems, like glass and polymer structures.

Lab-on-Chip

Femtosecond microfabrication is a hybrid approach that combines laser ablation and multi-photon polymerization for lab-on-chip applications. This enables the rapid production of channels and filters in arbitrary geometries for devices such as a microfluidic macromolecule separator and a liver-on-chip model.

Applying for Industries

Medical

Bioscience

Laser Nanofactory

Hybrid Fabrication

Laser Nanofactory workstation allows hybrid fabrication, meaning that various processes are supported by the same equipment. The two of our most frequently used processes are multiphoton polymerization and selective glass etching, however that is far from all!

Contract Manufacturing

Feasibility Studies

A feasibility study is composed of several steps, including researching methods for fabricating micro-structures, fabricating a micro-structure prototype, measuring and aligning the prototype with technical requirements, and finally preparing a study report.

Small Scale Production

Small-scale production is an essential step in the overall process of micro-structure fabrication, helping to ensure that the developed process is effective, efficient, and capable of producing high-quality micro-structures at scale.

Related Publications

Single-chip based contactless conductivity detection system for multi-channel separations

A. Maruška, T. Drevinskas, M. Stankevičius, K. Bimbiraitė-Survilienė, V. Kaškonienė, L. Jonušauskas, R. Gadonas, S. Nilsson, and O. Kornyšova. Anal. Methods, 2021, 13, 141–146, (2021). DOI: 10.1039/D0AY01882A.